Short answer: Jordan Metzner, who has genetically high cholesterol, demos a 3D liver and intestine model where turning on Crestor, then Zetia and Repatha, visibly reduces LDL particles. He suggests cardiologists could build such models for patients in real time.
Watch this answer from Episode 13 (starts at 2:06) · Episode 13 notes and transcript
From Episode 13: AI Built My Liver + We 3D Printed Our Podcast (Reddit x Google, Lyft x Waymo News), starting at 2:06.
Jordan Metzner [2:05]: Okay. Cool. So a little background here and maybe a little personal information, but I have historically and genetically high cholesterol. It's a pretty common trait. I think statins, the statins, which are the cholesterol medications, are the highest prescribed drugs, like, The United States or something like that. So this is obviously, like, a pretty common problem. I know a lot of people are on statins. So, I take all these medications, but you don't really know, like, what's happening, how they work, where do they work in your body. I thought this was, a really good use case for AI, both for kind of the personal consumer as, a way where, like, after your doctor's office, you could maybe come home and build something like this for yourself, but also great, maybe for medical professionals as well. So, if you are a pulmonologist or a cardiologist, you could kinda build these models in real time for your patients and give them a little bit idea of how this all works.
Jordan Metzner [2:58]: So I've got labels here, but, this giant yellow thing is your liver. And here you can see the enzymes and you can see the LDL floating around. Here's the intestines and you can see the blood vessels. And, I can zoom in. In fact, like, I can even do some other things like rotate it, check it out from different views here. So this is a full three-dimensional model of liver and intestines. Alright? So we'll jump back out kind of to the port to the outer view and the most common statin is Crestor. I think Lipitor is also equally common maybe. But what you can do here is you can turn it on and now Crestor is on and you can see that there's a slight change. Now this is only five milligrams of Crestor, but as I start to increase the dose, you'll see it's it's impacting the LDL cholesterol. And what you can see here is you have these other medications that you can add on as well. And so slowly as you start to add on these medications, this is Zetia, which is another type of cholesterol medication, and then ultimately Repatha, which is a third cholesterol medication, you can see that the LDL cholesterol has diminished significantly, and that's these, like, these dots that are floating around here. So, if we were to start all over, you'd see kind of look how much more LDL there is inside the body. And then, as you obviously turn on these medications and turn up the Crestor, and then you can see this actually from different angles.
Jordan Metzner [4:41]: So you can see the impact from the intestine and all the way through. You can zoom out and then you can see kind of like, what impact having Repatha or no, having Crestor now.
Sam Nadler [4:55]: Really cool visual, Jordan. I think it, really could be impactful just as to understand what your own medications do for your body. I know personally, I'm always a bit oblivious with anything medical. Just kinda trust my doctor and hope for the best, and hopefully, it has an impact. And but I think this is a really quick way you can get a deeper understanding of what the intended impact is. And then secondly, I would say, I'm assuming this took you just a couple minutes to build. Imagine having a tool at the, doctor's disposal just to as they're prescribing something or even more a bit more complicated, they could just, show a quick visual to their patients to kind of ramp them and educate them a bit better about their, care plan. So I think a really interesting way to use it. I'm also just thinking how quickly Claude developed this visual, like, what as outside of medicine, what visuals could be, really impactful in other industries. I don't know whether it's agriculture or coaching or I can't even you know, off the top of my head, I can't think of anything too innovative, but really cool use case.
